pI: 5.6698 |
Length (AA): 632 |
MW (Da): 70626 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
35 | 160 | 2gd5 (A) | 19 | 161 | 14.00 | 0 | 0.03 | 0.498242 | -0.69 |
106 | 356 | 3qoy (A) | 3 | 241 | 23.00 | 0 | 1 | 0.919207 | -0.17 |
120 | 349 | 3qoy (A) | 17 | 234 | 28.00 | 0.00000011 | 1 | 0.873483 | -0.27 |
158 | 347 | 4reo (A) | 40 | 226 | 30.00 | 0.000000097 | 1 | 0.751391 | 0.22 |
227 | 374 | 1qf6 (A) | 14 | 134 | 31.00 | 0.23 | 1 | 0.439143 | 1.26 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127255)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G42710 | ribosomal protein L1p/L10e family protein |
Arabidopsis thaliana | AT3G63490 | 50S ribosomal protein L1 |
Babesia bovis | BBOV_IV010190 | ribosomal protein L1, putative |
Brugia malayi | Bm1_24175 | L1P family of ribosomal proteins containing protein |
Candida albicans | CaO19.5698 | likely mitochondrial ribosomal protein similar to S. cerevisiae MRPL1 (YDR116C) mitochondrial ribosome large subunit protein L1 |
Caenorhabditis elegans | CELE_F33D4.5 | Protein F33D4.5 |
Chlamydia trachomatis | CT_318 | 50S ribosomal protein L1 |
Drosophila melanogaster | Dmel_CG7494 | mitochondrial ribosomal protein L1 |
Escherichia coli | b3984 | 50S ribosomal subunit protein L1 |
Echinococcus granulosus | EgrG_000043600 | 50S ribosomal protein L1 |
Echinococcus multilocularis | EmuJ_000043600 | 50S ribosomal protein L1 |
Homo sapiens | ENSG00000169288 | mitochondrial ribosomal protein L1 |
Loa Loa (eye worm) | LOAG_04857 | hypothetical protein |
Mycobacterium leprae | ML1904c | PROBABLE 50S RIBOSOMAL PROTEIN L1 RPLA |
Mus musculus | ENSMUSG00000029486 | mitochondrial ribosomal protein L1 |
Mycobacterium tuberculosis | Rv0641 | 50S ribosomal protein L1 RplA |
Mycobacterium ulcerans | MUL_0727 | 50S ribosomal protein L1 |
Neospora caninum | NCLIV_007370 | Ribosomal protein L1, related |
Neospora caninum | NCLIV_019130 | hypothetical protein |
Oryza sativa | 4338667 | Os05g0388500 |
Oryza sativa | 4341246 | Os06g0546400 |
Onchocerca volvulus | OVOC12122 | 39S ribosomal protein L1, mitochondrial homolog |
Plasmodium berghei | PBANKA_0608400 | 50S ribosomal protein L1, apicoplast, putative |
Plasmodium berghei | PBANKA_1221500 | 50S ribosomal protein L1, mitochondrial, putative |
Plasmodium falciparum | PF3D7_1210000 | 50S ribosomal protein L1, apicoplast, putative |
Plasmodium falciparum | PF3D7_0710900 | 50S ribosomal protein L1, mitochondrial, putative |
Plasmodium knowlesi | PKNH_0109600 | 50S ribosomal protein L1, mitochondrial, putative |
Plasmodium knowlesi | PKNH_1310000 | 50S ribosomal protein L1, apicoplast, putative |
Plasmodium vivax | PVX_088080 | 50S ribosomal protein L1, mitochondrial, putative |
Plasmodium yoelii | PY05786 | L1P family of ribosomal proteins, putative |
Plasmodium yoelii | PY03485 | L1P family of ribosomal proteins, putative |
Saccharomyces cerevisiae | YDR116C | mitochondrial 54S ribosomal protein MRPL1 |
Schistosoma japonicum | Sjp_0316730 | expressed protein |
Schistosoma japonicum | Sjp_0206910 | IPR002143,Ribosomal protein L1,domain-containing |
Schistosoma mansoni | Smp_001960 | 50S ribosomal protein L1 |
Schmidtea mediterranea | mk4.007388.01 | 39S ribosomal protein L1, mitochondrial |
Trypanosoma congolense | TcIL3000_0_51340 | ribosomal protein L1, putative |
Toxoplasma gondii | TGME49_244580 | L1P family of ribosomal protein |
Toxoplasma gondii | TGME49_252270 | L1P family of ribosomal protein |
Treponema pallidum | TP0238 | 50S ribosomal protein L1 |
Theileria parva | TP01_0654 | 60S ribosomal protein L1, putative |
Theileria parva | TP01_1119 | ribosomal protein L1, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0650 | 50S ribosomal protein L1 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu653 | Mycobacterium tuberculosis | non-essential | nmpdr |
b3984 | Escherichia coli | essential | goodall |
CELE_F33D4.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F33D4.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F33D4.5 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_0608400 | Plasmodium berghei | Essential | plasmo |
PBANKA_1221500 | Plasmodium berghei | Essential | plasmo |
TGME49_244580 | Toxoplasma gondii | Probably essential | sidik |
TGME49_252270 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.